Description
Product Characteristics: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of gSAP in rat tissue homogenates.
Target Information: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD\, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1\, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP\, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]